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Target
DNA polymerase beta
Ligand
BDBM50242088
Substrate
n/a
Meas. Tech.
ChEMBL_550598 (CHEMBL999199)
IC50
15300±n/a nM
Citation
 Prakash Chaturvedula, VS; Hecht, SM; Gao, Z; Jones, SH; Feng, X; Kingston, DG New neolignans that inhibit DNA polymerase beta lyase. J Nat Prod 67:964-7 (2004) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50242088
Synonyms:
(7S,8R,1'S,5'S,6'R)-delta 2',8'-5',6'-Dihydroxy-3'-methoxy-3,4-methylenedioxy-4'-oxo-8.1',7.5'-neolignan | CHEMBL511272
Type:
Small organic molecule
Emp. Form.:
C20H22O6
Mol. Mass.:
358.3851
SMILES:
COC1=C[C@]2(CC=C)[C@H](C)[C@@H](c3ccc4OCOc4c3)[C@](O)([C@@H]2O)C1=O |r,t:2,TLB:23:22:10.8:3.24.2|
Structure:
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