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Target
B1 bradykinin receptor
Ligand
BDBM50264399
Substrate
n/a
Meas. Tech.
ChEMBL_535280 (CHEMBL982605)
IC50
524±n/a nM
Citation
 Guo, Q; Chandrasekhar, J; Ihle, D; Wustrow, DJ; Chenard, BL; Krause, JE; Hutchison, A; Alderman, D; Cheng, C; Cortright, D; Broom, D; Kershaw, MT; Simmermacher-Mayer, J; Peng, Y; Hodgetts, KJ 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists. Bioorg Med Chem Lett 18:5027-31 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
BDKRB1 | BKRB1_MACFA
Type:
PROTEIN
Mol. Mass.:
40231.64
Organism:
Macaca fascicularis
Description:
ChEMBL_535280
Residue:
352
Sequence:
MASWPPLQLQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICSFGLLGNLFVLLVFLLPRRRLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGIIKANLFISIFLVVAISQDRYCVLVHPMASRRRQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILAFLLPLAAIIFFNYHILASLRGREEVSRTRCGGSKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFLAFTNSSLNPVIYVFAGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50264399
Synonyms:
1-Benzyl-1H-benzoimidazole-2-carboxylic acid [2-(1H-indazol-6-ylcarbamoyl)-ethyl]-amide | CHEMBL489808
Type:
Small organic molecule
Emp. Form.:
C25H22N6O2
Mol. Mass.:
438.4812
SMILES:
O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2cn[nH]c2c1
Structure:
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