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Target
Tyrosine-protein kinase ITK/TSK
Ligand
BDBM50275741
Substrate
n/a
Meas. Tech.
ChEMBL_497468 (CHEMBL1006237)
IC50
110±n/a nM
Citation
 Winters, MP; Robinson, DJ; Khine, HH; Pullen, SS; Woska, JR; Raymond, EL; Sellati, R; Cywin, CL; Snow, RJ; Kashem, MA; Wolak, JP; King, J; Kaplita, PV; Liu, LH; Farrell, TM; DesJarlais, R; Roth, GP; Takahashi, H; Moriarty, KJ 5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk). Bioorg Med Chem Lett 18:5541-4 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ITK/TSK
Synonyms:
EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:
Protein
Mol. Mass.:
71839.20
Organism:
Homo sapiens (Human)
Description:
Q08881
Residue:
620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
  
Inhibitor
Name:
BDBM50275741
Synonyms:
4-cyano-N-(1-(3-methoxypropyl)-5-(((1-methylpiperidin-4-yl)methylamino)methyl)-1H-benzo[d]imidazol-2-yl)benzamide | CHEMBL486755
Type:
Small organic molecule
Emp. Form.:
C27H34N6O2
Mol. Mass.:
474.5979
SMILES:
COCCCn1c(NC(=O)c2ccc(cc2)C#N)nc2cc(CNCC3CCN(C)CC3)ccc12
Structure:
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