Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50275478
Substrate
n/a
Meas. Tech.
ChEMBL_493369 (CHEMBL940410)
IC50
3.37±n/a nM
Citation
Lee, SH; Seo, HJ; Lee, SH; Jung, ME; Park, JH; Park, HJ; Yoo, J; Yun, H; Na, J; Kang, SY; Song, KS; Kim, MA; Chang, CH; Kim, J; Lee, J Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity. J Med Chem 51:7216-33 (2009) [PubMed] Article
More Info.:
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Inhibitor
Name:
BDBM50275478
Synonyms:
2-(4-((2H-tetrazol-2-yl)methyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-oxadiazole | CHEMBL487586
Type:
Small organic molecule
Emp. Form.:
C23H19Cl3N8O
Mol. Mass.:
529.809
SMILES:
CC(C)(C)c1nnc(o1)-c1nn(c(c1Cn1ncnn1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl