Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50265921
Substrate
n/a
Meas. Tech.
ChEMBL_540171 (CHEMBL1029012)
EC50
91±n/a nM
Citation
 Charton, J; Deprez-Poulain, R; Hennuyer, N; Tailleux, A; Staels, B; Deprez, B Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. Bioorg Med Chem Lett 19:489-92 (2008) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50265921
Synonyms:
3-(4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)phenyl)-1,2,4-oxadiazol-5(4H)-one | CHEMBL468608
Type:
Small organic molecule
Emp. Form.:
C24H24N2O2
Mol. Mass.:
372.4596
SMILES:
CC1(C)CCC(C)(C)c2cc(ccc12)C#Cc1ccc(cc1)-c1nc(=O)o[nH]1
Structure:
Search PDB for entries with ligand similarity: