Target
Adenosine receptor A2a
Ligand
BDBM50254012
Substrate
n/a
Meas. Tech.
ChEMBL_560532 (CHEMBL1021382)
Ki
0.7±n/a nM
Citation
 Gillespie, RJBamford, SJBotting, RComer, MDenny, SGaur, SGriffin, MJordan, AMKnight, ARLerpiniere, JLeonardi, SLightowler, SMcAteer, SMerrett, AMisra, APadfield, AReece, MSaadi, MSelwood, DLStratton, GCSurry, DTodd, RTong, XRuston, VUpton, RWeiss, SM Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J Med Chem 52:33-47 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Human
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50254012
Synonyms:
3-(4-Amino-3-fluorobenzyl)-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine | CHEMBL517886
Type:
Small organic molecule
Emp. Form.:
C15H12FN7O
Mol. Mass.:
325.3005
SMILES:
Nc1nc(-c2ccco2)c2nnn(Cc3ccc(N)c(F)c3)c2n1
Structure:
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