Reaction Details Report a problem with these data
Target
Proto-oncogene Wnt-3
Ligand
BDBM50265549
Substrate
n/a
Meas. Tech.
ChEMBL_560815 (CHEMBL1012645)
EC50
460±n/a nM
Citation
Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 52:105-16 (2009) [PubMed] Article
More Info.:
Target
Name:
Proto-oncogene Wnt-3
Synonyms:
INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39653.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_576549
Residue:
355
Sequence:
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
Inhibitor
Name:
BDBM50265549
Synonyms:
CHEMBL507695 | N-{1-[1-(Cyclohexylcarbonyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C30H36F3N3O6S2
Mol. Mass.:
655.749
SMILES:
FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)C1CCCCC1)S(=O)(=O)c1ccccc1 |r|