Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50255739
Substrate
n/a
Meas. Tech.
ChEMBL_516084 (CHEMBL982454)
IC50
5.5±n/a nM
Citation
 Cherney, RJ; Brogan, JB; Mo, R; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Molino, BF; Carter, PH; Decicco, CP Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett 19:597-601 (2009) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50255739
Synonyms:
(+/-)-N-(2-(4-(dimethylamino)-2-(4-methylbenzylamino)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide | CHEMBL481202
Type:
Small organic molecule
Emp. Form.:
C26H33F3N4O2
Mol. Mass.:
490.561
SMILES:
CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: