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Target
Renin
Ligand
BDBM50281244
Substrate
n/a
Meas. Tech.
ChEBML_196101
pH
7±n/a
IC50
>1000000±n/a nM
Comments
extracted
Citation
 Poss, MA; Reid, JA; Free, CA; Rogers, W; Weber, H; Ryono, DE; Dejneka, T; DeForrest, JM; Waldron, TL; Brittain, RJ; Weller, HN; Cimarusti, MP; Petrillo, EW Diol sulfonamides: A potent and novel class of inhibitors of human renin Bioorg Med Chem Lett 3:2739-2744 (1993)    Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50281244
Synonyms:
(S)-2-Amino-N-[4-((S,R,R)-butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butyl]-3-(3H-imidazol-4-yl)-propionamide | CHEMBL90659
Type:
Small organic molecule
Emp. Form.:
C21H39N5O5S
Mol. Mass.:
473.63
SMILES:
CCCCNS(=O)(=O)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1
Structure:
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