Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50283284
Substrate
n/a
Meas. Tech.
ChEBML_79814
IC50
2±n/a nM
Citation
Kim, BM; Vacca, JP; Guare, JP; Hanifin, CM; Michelson, SR; Darke, P; Zugay, JA; Emini, EA; Schleif, W; Lin, JH; Chen, IW; Vastag, K; Ostovic, D; Anderson, PS; Huff, JR A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability Bioorg Med Chem Lett 4:2273-2278 (1994) Article
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM50283284
Synonyms:
CHEMBL75310 | {(1S,2R)-1-Benzyl-3-[2-((R)-tert-butylcarbamoyl)-4-(6-methyl-pyridin-3-ylmethyl)-piperazin-1-yl]-2-hydroxy-propyl}-carbamic acid (R)-2-isopropyl-1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl ester
Type:
Small organic molecule
Emp. Form.:
C34H51N5O6S
Mol. Mass.:
657.864
SMILES:
CC(C)[C@@H]1[C@@H](CCS1(=O)=O)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN1CCN(Cc2ccc(C)nc2)C[C@H]1C(=O)NC(C)(C)C