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Target
Endothelin-1 receptor
Ligand
BDBM50288539
Substrate
n/a
Meas. Tech.
ChEMBL_63188 (CHEMBL679791)
IC50
8700±n/a nM
Citation
 Cheng, XM; Lee, C; Klutchko, S; Winters, T; Reynolds, EE; Welch, KM; Flynn, MA; Doherty, AM Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists Bioorg Med Chem Lett 6:2999-3002 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50288539
Synonyms:
Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid benzo[1,3]dioxol-5-ylmethyl ester | CHEMBL316648
Type:
Small organic molecule
Emp. Form.:
C30H21NO6
Mol. Mass.:
491.4908
SMILES:
O=C(OCc1ccc2OCOc2c1)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Structure:
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