Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50293039
Substrate
n/a
Meas. Tech.
ChEMBL_519455 (CHEMBL950881)
IC50
>77000±n/a nM
Citation
 Merritt, JR; Liu, J; Quadros, E; Morris, ML; Liu, R; Zhang, R; Jacob, B; Postelnek, J; Hicks, CM; Chen, W; Kimble, EF; Rogers, WL; O'Brien, L; White, N; Desai, H; Bansal, S; King, G; Ohlmeyer, MJ; Appell, KC; Webb, ML Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists. J Med Chem 52:1295-301 (2010) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50293039
Synonyms:
(R)-N2-(4-Methoxybenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide | CHEMBL517141
Type:
Small organic molecule
Emp. Form.:
C21H24ClN3O3
Mol. Mass.:
401.887
SMILES:
COc1ccc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)cc1 |r|
Structure:
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