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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50296116
Substrate
n/a
Meas. Tech.
ChEMBL_579418 (CHEMBL1053173)
IC50
14±n/a nM
Citation
 Bonjoch, J; Diaba, F; Pagès, L; Pérez, D; Soca, L; Miralpeix, M; Vilella, D; Anton, P; Puig, C Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists. Bioorg Med Chem Lett 19:4299-302 (2009) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50296116
Synonyms:
3-(5-((2-(7-chloroquinolin-2-yl)benzofuran-5-yl)methyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)propanoic acid | CHEMBL559928
Type:
Small organic molecule
Emp. Form.:
C32H26ClN3O3
Mol. Mass.:
536.02
SMILES:
OC(=O)CCN1CCc2c(C1)c1ccccc1n2Cc1ccc2oc(cc2c1)-c1ccc2ccc(Cl)cc2n1
Structure:
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