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Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50298983
Substrate
n/a
Meas. Tech.
ChEMBL_588224 (CHEMBL1043978)
IC50
210±n/a nM
Citation
Sasaki, T; Nagase, T; Takahashi, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. Bioorg Med Chem 17:5639-47 (2009) [PubMed] Article
More Info.:
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_HUMAN | ELOVL6 | FACE | LCE
Type:
PROTEIN
Mol. Mass.:
31392.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572238
Residue:
265
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE
Inhibitor
Name:
BDBM50298983
Synonyms:
(1R*,4S*,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(propylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide | CHEMBL575155
Type:
Small organic molecule
Emp. Form.:
C20H30N2O4S
Mol. Mass.:
394.528
SMILES:
CCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@@H](C2)C(=O)Nc1ccc(OC(C)C)cc1 |r,TLB:3:6:13.12:9.10,THB:14:12:7.6:9.10|