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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50301015
Substrate
n/a
Meas. Tech.
ChEMBL_598137 (CHEMBL1039167)
IC50
96±n/a nM
Citation
 Zhang, N; Wu, B; Boschelli, DH; Golas, JM; Boschelli, F 4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors. Bioorg Med Chem Lett 19:5071-4 (2009) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50301015
Synonyms:
4-(2,4-Dichloro-5-methoxy-phenylamino)-7-[5-(1-oxo-1lambda*4*-thiomorpholin-4-ylmethyl)-pyridin-2-yl]-quinoline-3-carbonitrile | CHEMBL566577
Type:
Small organic molecule
Emp. Form.:
C27H23Cl2N5O2S
Mol. Mass.:
552.475
SMILES:
COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCS(=O)CC3)cn2)C#N)c(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: