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Target
Neutrophil elastase
Ligand
BDBM50303363
Substrate
n/a
Meas. Tech.
ChEMBL_595760 (CHEMBL1045283)
Kd
9.5±n/a nM
Citation
 Mulchande, J; Oliveira, R; Carrasco, M; Gouveia, L; Guedes, RC; Iley, J; Moreira, R 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem 53:241-53 (2010) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50303363
Synonyms:
2-(4-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)benzylthio)benzo[d]-oxazole-6-carboxylic acid | CHEMBL568217
Type:
Small organic molecule
Emp. Form.:
C22H20N2O5S
Mol. Mass.:
424.47
SMILES:
CCC1(CC)C(=O)N(C1=O)c1ccc(CSc2nc3cc(ccc3o2)C(O)=O)cc1
Structure:
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