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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50311626
Substrate
n/a
Meas. Tech.
ChEMBL_618650 (CHEMBL1101699)
IC50
12±n/a nM
Citation
 Hategan, G; Polozov, AM; Zeller, W; Cao, H; Mishra, RK; Kiselyov, AS; Ramirez, J; Halldorsdottir, G; Andrésson, T; Gurney, ME; Singh, J Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists. Bioorg Med Chem Lett 19:6797-800 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50311626
Synonyms:
CHEMBL1079409 | N-(5-(1-(3,4-difluorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)isoxazol-3-yl)-2,3,4-trifluorobenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C25H15F6N3O3S
Mol. Mass.:
551.46
SMILES:
Cc1cn(Cc2ccc(F)c(F)c2)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2F)no1
Structure:
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