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Target
Cholesteryl ester transfer protein
Ligand
BDBM50312708
Substrate
n/a
Meas. Tech.
ChEMBL_615620 (CHEMBL1104194)
IC50
4000±n/a nM
Citation
 Schmeck, C; Gielen-Haertwig, H; Vakalopoulos, A; Bischoff, H; Li, V; Wirtz, G; Weber, O Novel tetrahydrochinoline derived CETP inhibitors. Bioorg Med Chem Lett 20:1740-3 (2010) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50312708
Synonyms:
(S)-(2-cyclopentyl-5-hydroxy-7,7-dimethyl-4-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroquinolin-3-yl)(4-(trifluoromethyl)phenyl)methanone | CHEMBL1081083
Type:
Small organic molecule
Emp. Form.:
C28H33F3N2O2
Mol. Mass.:
486.569
SMILES:
CC1(C)C[C@H](O)c2c(C1)nc(C1CCCC1)c(C(=O)c1ccc(cc1)C(F)(F)F)c2N1CCCC1 |r|
Structure:
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