Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50325720
Substrate
n/a
Meas. Tech.
ChEMBL_652569 (CHEMBL1225772)
IC50
32±n/a nM
Citation
Merritt, JR; James, R; Paradkar, VM; Zhang, C; Liu, R; Liu, J; Jacob, B; Chiriac, C; Ohlmeyer, MJ; Quadros, E; Wines, P; Postelnek, J; Hicks, CM; Chen, W; Kimble, EF; O'Brien, L; White, N; Desai, H; Appell, KC; Webb, ML Novel pyrrolidine heterocycles as CCR1 antagonists. Bioorg Med Chem Lett 20:5477-9 (2010) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
Inhibitor
Name:
BDBM50325720
Synonyms:
(R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide | CHEMBL1224120
Type:
Small organic molecule
Emp. Form.:
C21H19ClF3N5O
Mol. Mass.:
449.857
SMILES:
FC(F)(F)c1ccc(NC(=O)N2CCC[C@@H]2c2ncnn2Cc2ccc(Cl)cc2)cc1 |r|