Reaction Details Report a problem with these data
Target
Placenta growth factor
Ligand
BDBM50339212
Substrate
n/a
Meas. Tech.
ChEMBL_736104 (CHEMBL1692887)
Kd
9±n/a nM
Citation
 Bower, KE; Lam, SN; Oates, BD; Del Rosario, JR; Corner, E; Osothprarop, TF; Kinhikar, AG; Hoye, JA; Preston, RR; Murphy, RE; Campbell, LA; Huang, H; Jimenez, J; Cao, X; Chen, G; Ainekulu, ZW; Datt, AB; Levin, NJ; Doppalapudi, VR; Pirie-Shepherd, SR; Bradshaw, C; Woodnutt, G; Lappe, RW Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. J Med Chem 54:1256-65 (2011) [PubMed]  Article 
Target
Name:
Placenta growth factor
Synonyms:
PGF | PGFL | PLGF | PLGF_HUMAN
Type:
PROTEIN
Mol. Mass.:
24794.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942634
Residue:
221
Sequence:
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
  
Inhibitor
Name:
BDBM50339212
Synonyms:
CHEMBL1689483
Type:
Small organic molecule
Emp. Form.:
C116H168N28O32S2
Mol. Mass.:
2530.874
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C |r|
Structure:
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