Reaction Details Report a problem with these data
Target
Placenta growth factor
Ligand
BDBM50339225
Substrate
n/a
Meas. Tech.
ChEMBL_736105 (CHEMBL1692888)
IC50
>10000000±n/a nM
Citation
 Bower, KE; Lam, SN; Oates, BD; Del Rosario, JR; Corner, E; Osothprarop, TF; Kinhikar, AG; Hoye, JA; Preston, RR; Murphy, RE; Campbell, LA; Huang, H; Jimenez, J; Cao, X; Chen, G; Ainekulu, ZW; Datt, AB; Levin, NJ; Doppalapudi, VR; Pirie-Shepherd, SR; Bradshaw, C; Woodnutt, G; Lappe, RW Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. J Med Chem 54:1256-65 (2011) [PubMed]  Article 
Target
Name:
Placenta growth factor
Synonyms:
PGF | PGFL | PLGF | PLGF_HUMAN
Type:
PROTEIN
Mol. Mass.:
24794.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942634
Residue:
221
Sequence:
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
  
Inhibitor
Name:
BDBM50339225
Synonyms:
(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(2-amino-2-oxoethyl)-6-((5S,8S,11S)-16-amino-5-carbamoyl-16-imino-8-isopropyl-7,10-dioxo-2-thia-6,9,15-triazahexadecan-11-ylcarbamoyl)-20-isopropyl-26-methyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid | CHEMBL1689451
Type:
Small organic molecule
Emp. Form.:
C78H113N23O19S3
Mol. Mass.:
1773.07
SMILES:
CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r,wU:62.63,70.71,107.111,103.106,84.87,4.4,12.19,32.32,44.52,wD:23.22,28.28,95.98,8.8,36.40,(-4.06,-51.01,;-2.73,-50.23,;-2.73,-48.69,;-1.39,-47.92,;-1.39,-46.39,;-.05,-45.61,;1.28,-46.39,;1.28,-47.92,;2.61,-45.61,;3.96,-46.39,;5.29,-45.61,;5.29,-44.07,;6.62,-46.39,;6.62,-47.92,;5.29,-48.69,;5.29,-50.23,;3.96,-51.01,;3.96,-52.55,;5.29,-53.32,;2.61,-53.32,;7.96,-45.62,;9.28,-46.39,;9.28,-47.92,;10.62,-45.61,;10.62,-44.08,;9.3,-43.26,;9.31,-41.69,;7.97,-40.88,;7.98,-39.33,;6.66,-38.56,;5.31,-39.31,;5.31,-40.85,;3.97,-38.56,;2.64,-39.33,;1.32,-38.57,;1.32,-37.04,;-.03,-39.35,;-.01,-40.88,;-1.35,-41.67,;-2.71,-40.91,;-1.33,-43.23,;-1.34,-38.58,;-1.33,-37.02,;.02,-36.25,;-2.67,-36.24,;-2.67,-34.68,;-1.31,-33.91,;.03,-34.7,;1.38,-33.93,;1.39,-32.37,;.04,-31.59,;-1.31,-32.36,;-4.03,-37.01,;-5.37,-36.22,;-6.72,-37,;-5.36,-34.67,;3.98,-37.03,;5.29,-36.25,;2.63,-36.25,;9.35,-38.57,;10.68,-39.31,;9.29,-37.09,;10.62,-36.31,;10.65,-34.78,;9.29,-33.99,;7.94,-34.76,;9.31,-32.44,;11.97,-37.1,;11.95,-38.64,;13.3,-36.34,;14.62,-37.14,;15.95,-36.39,;15.96,-34.85,;17.23,-33.97,;16.78,-32.5,;15.24,-32.49,;14.23,-31.34,;12.72,-31.64,;12.24,-33.1,;13.25,-34.24,;14.74,-33.94,;14.61,-38.67,;13.27,-39.43,;15.93,-39.45,;19.88,-37.18,;21.21,-36.4,;21.21,-34.88,;22.54,-37.18,;19.89,-38.73,;21.23,-39.48,;18.59,-39.48,;18.57,-41.03,;17.23,-41.81,;15.9,-41.06,;17.26,-43.35,;15.92,-44.12,;14.59,-43.36,;15.92,-45.66,;14.6,-46.43,;17.26,-46.42,;18.72,-45.95,;19.63,-47.2,;18.72,-48.43,;17.26,-47.95,;15.91,-48.71,;15.91,-50.25,;14.59,-47.94,;13.26,-48.69,;13.24,-50.24,;11.91,-51.01,;10.66,-50.14,;9.44,-51.08,;9.95,-52.52,;11.48,-52.49,;11.94,-47.93,;10.6,-48.69,;11.94,-46.39,;2.61,-44.05,;3.96,-43.27,;1.26,-43.28,;-2.73,-45.61,;-4.06,-46.39,;-2.73,-44.07,)|
Structure:
Search PDB for entries with ligand similarity: