Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50341701
Substrate
n/a
Meas. Tech.
ChEMBL_743334 (CHEMBL1767581)
Ki
>100000±n/a nM
Citation
Baragaña, B; McCarthy, O; Sánchez, P; Bosch-Navarrete, C; Kaiser, M; Brun, R; Whittingham, JL; Roberts, SM; Zhou, XX; Wilson, KS; Johansson, NG; González-Pacanowska, D; Gilbert, IH β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem 19:2378-91 (2011) [PubMed] Article
More Info.:
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
Inhibitor
Name:
BDBM50341701
Synonyms:
CHEMBL1766637 | rac-1-[2-(tert-Butyldiphenylsilyloxyethylamido)-4-trityloxybutyl]uracil
Type:
Small organic molecule
Emp. Form.:
C46H49N3O5Si
Mol. Mass.:
751.9839
SMILES:
CC(C)(C)[Si](OCCNC(=O)C(CCOC(c1ccccc1)(c1ccccc1)c1ccccc1)Cn1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1