Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50346146
Substrate
n/a
Meas. Tech.
ChEMBL_749250 (CHEMBL1785133)
IC50
3000±n/a nM
Citation
Alvarez, S; Alvarez, R; Khanwalkar, H; Germain, P; Lemaire, G; Rodríguez-Barrios, F; Gronemeyer, H; de Lera, AR Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists. Bioorg Med Chem 17:4345-59 (2009) [PubMed] Article
More Info.:
Target
Name:
Retinoic acid receptor gamma
Synonyms:
Nr1b3 | RARG_MOUSE | Rarg
Type:
PROTEIN
Mol. Mass.:
50896.02
Organism:
Mus musculus
Description:
ChEMBL_196161
Residue:
458
Sequence:
MATNKERLFAPGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQSPQPDQGP
Inhibitor
Name:
BDBM50346146
Synonyms:
CHEMBL1783651 | rac-4-[3-(8,8-Dimethyl-5-(phenylethynyl)-7,8-dihydronaphthalen-2-yl)-4,5-dihydroisoxazol-5-yl]benzoic Acid
Type:
Small organic molecule
Emp. Form.:
C30H25NO3
Mol. Mass.:
447.5244
SMILES:
CC1(C)CC=C(C#Cc2ccccc2)c2ccc(cc12)C1=NOC(C1)c1ccc(cc1)C(O)=O |t:4,23|