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Target
Transcription factor p65
Ligand
BDBM50346333
Substrate
n/a
Meas. Tech.
ChEMBL_749381 (CHEMBL1785171)
IC50
>10000±n/a nM
Citation
 Ren, Y; Matthew, S; Lantvit, DD; Ninh, TN; Chai, H; Fuchs, JR; Soejarto, DD; de Blanco, EJ; Swanson, SM; Kinghorn, AD Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues. J Nat Prod 74:1117-25 (2011) [PubMed]  Article 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM50346333
Synonyms:
(1S,3aR,5R,12aR)-3,3a,4,5-tetrahydro-8,10-dihydroxy-3,3-dimethyl-1-(3-methyl-2-buten-1-yl)-1, 5-methano-1H,7H-furo[3,4-d]xanthene-7,13-dione | CHEMBL1782238
Type:
Small organic molecule
Emp. Form.:
C23H24O6
Mol. Mass.:
396.4331
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6][C@]12[#8]C([#6])([#6])[#6@H]3-[#6]-[#6@H](-[#6]=[#6]4-[#6](=O)-c5c(-[#8])cc(-[#8])cc5-[#8][C@]134)-[#6]2=O |r,t:13,TLB:28:27:26:6.7,28:27:13.14:11.10,4:5:13.14:11.10,6:5:13.14:11.10,THB:13:12:26:6.7|
Structure:
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