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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50333651
Substrate
n/a
Meas. Tech.
ChEMBL_760981 (CHEMBL1815009)
IC50
400±n/a nM
Citation
 Gaspar, A; Silva, T; Yáñez, M; Vina, D; Orallo, F; Ortuso, F; Uriarte, E; Alcaro, S; Borges, F Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors. J Med Chem 54:5165-73 (2011) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50333651
Synonyms:
4-oxo-N-phenyl-4H-chromene-3-carboxamide | CHEMBL1643120
Type:
Small organic molecule
Emp. Form.:
C16H11NO3
Mol. Mass.:
265.2634
SMILES:
O=C(Nc1ccccc1)c1coc2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: