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Target
Estrogen receptor
Ligand
BDBM50354959
Substrate
n/a
Meas. Tech.
ChEMBL_772848 (CHEMBL1837720)
EC50
>2680±n/a nM
Citation
 Roberts, LR; Armor, D; Barker, C; Bent, A; Bess, K; Brown, A; Favor, DA; Ellis, D; Irving, SL; MacKenny, M; Phillips, C; Pullen, N; Stennett, A; Strand, L; Styles, M Sulfonamides as selective oestrogen receptorß agonists. Bioorg Med Chem Lett 21:5680-3 (2011) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50354959
Synonyms:
CHEMBL1836909
Type:
Small organic molecule
Emp. Form.:
C18H18F3NO4S
Mol. Mass.:
401.4
SMILES:
Oc1ccc(cc1)S(=O)(=O)N(CC(O)(c1ccccc1)C(F)(F)F)C1CC1
Structure:
Search PDB for entries with ligand similarity: