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Target
SRSF protein kinase 3
Ligand
BDBM50026612
Substrate
n/a
Meas. Tech.
ChEMBL_774558 (CHEMBL1908775)
Kd
12±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
SRSF protein kinase 3
Synonyms:
MSSK-1 | MSSK1 | Muscle-specific serine kinase 1 | SR-protein-specific kinase 3 | SRPK3 | SRPK3_HUMAN | SRSF protein kinase 3 | STK23 | Serine/arginine-rich protein-specific kinase 3 | Serine/threonine-protein kinase 23 | Serine/threonine-protein kinase SRPK3
Type:
PROTEIN
Mol. Mass.:
62021.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655942
Residue:
567
Sequence:
MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP
  
Inhibitor
Name:
BDBM50026612
Synonyms:
BIBF-1120 | Nintedanib | US10981896, Compound Nintedanib | US11046672, Nintedanib | US11208381, Nintedanib | Vargatef
Type:
Small organic molecule
Emp. Form.:
C31H33N5O4
Mol. Mass.:
539.6248
SMILES:
COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Structure:
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