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Target
Cyclin-dependent kinase 11B
Ligand
BDBM26300
Substrate
n/a
Meas. Tech.
ChEMBL_774188 (CHEMBL1908405)
Kd
1200±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 11B
Synonyms:
2.7.11.22 | CD11B_HUMAN | CDC2L1 | CDK11 | CDK11B | CLK-1 | Cell division cycle 2-like protein kinase 1 | Cell division protein kinase 11B | Cyclin-dependent kinase | Cyclin-dependent kinase 11 (CDK11) | Cyclin-dependent kinase 11B | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLREA | PK58 | p58 CLK-1
Type:
Protein
Mol. Mass.:
92685.77
Organism:
Homo sapiens (Human)
Description:
P21127
Residue:
795
Sequence:
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
  
Inhibitor
Name:
BDBM26300
Synonyms:
2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide | CHEMBL215152 | cid_16007391 | pyrazoloquinazoline deriv., 34
Type:
Small organic molecule
Emp. Form.:
C26H30FN7O3
Mol. Mass.:
507.5599
SMILES:
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1
Structure:
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