Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50362690
Substrate
n/a
Meas. Tech.
ChEMBL_797514 (CHEMBL1943344)
EC50
13±n/a nM
Citation
 Houze, JB; Zhu, L; Sun, Y; Akerman, M; Qiu, W; Zhang, AJ; Sharma, R; Schmitt, M; Wang, Y; Liu, J; Liu, J; Medina, JC; Reagan, JD; Luo, J; Tonn, G; Zhang, J; Lu, JY; Chen, M; Lopez, E; Nguyen, K; Yang, L; Tang, L; Tian, H; Shuttleworth, SJ; Lin, DC AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett 22:1267-70 (2012) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1_MOUSE | Ffar1 | Gpr40
Type:
PROTEIN
Mol. Mass.:
31818.80
Organism:
Mus musculus
Description:
ChEMBL_1454431
Residue:
300
Sequence:
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
  
Inhibitor
Name:
BDBM50362690
Synonyms:
AMG-837 | CHEMBL1829173
Type:
Small organic molecule
Emp. Form.:
C26H21F3O3
Mol. Mass.:
438.4383
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1 |r|
Structure:
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