Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50362696
Substrate
n/a
Meas. Tech.
ChEMBL_797511 (CHEMBL1943341)
EC50
1200±n/a nM
Citation
 Houze, JB; Zhu, L; Sun, Y; Akerman, M; Qiu, W; Zhang, AJ; Sharma, R; Schmitt, M; Wang, Y; Liu, J; Liu, J; Medina, JC; Reagan, JD; Luo, J; Tonn, G; Zhang, J; Lu, JY; Chen, M; Lopez, E; Nguyen, K; Yang, L; Tang, L; Tian, H; Shuttleworth, SJ; Lin, DC AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett 22:1267-70 (2012) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50362696
Synonyms:
CHEMBL1939642
Type:
Small organic molecule
Emp. Form.:
C20H22O4
Mol. Mass.:
326.3863
SMILES:
[#6]-[#8]-c1ccc(-[#6]-[#8]-c2ccc(cc2)-[#6](\[#6]-[#6](-[#8])=O)=[#6](\[#6])-[#6])cc1
Structure:
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