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Target
Vasoactive intestinal polypeptide receptor 1
Ligand
BDBM50241256
Substrate
n/a
Meas. Tech.
ChEMBL_807309 (CHEMBL1960402)
IC50
15000±n/a nM
Citation
 Harikrishnan, LS; Srivastava, N; Kayser, LE; Nirschl, DS; Kumaragurubaran, K; Roy, A; Gupta, A; Karmakar, S; Karatt, T; Mathur, A; Burford, NT; Chen, J; Kong, Y; Cvijic, M; Cooper, CB; Poss, MA; Trainor, GL; Wong, TW Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1). Bioorg Med Chem Lett 22:2287-90 (2012) [PubMed]  Article 
Target
Name:
Vasoactive intestinal polypeptide receptor 1
Synonyms:
PACAP type II receptor | PACAP-R-2 | PACAP-R2 | Pituitary adenylate cyclase-activating polypeptide type II receptor | VIP-R-1 | VIPR1_RAT | Vipr1
Type:
PROTEIN
Mol. Mass.:
52068.73
Organism:
Rattus norvegicus
Description:
ChEMBL_807309
Residue:
459
Sequence:
MRPPSPPHVRWLCVLAGALACALRPAGSQAASPQHECEYLQLIEIQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAPIHGYNISRSCTEEGWSQLEPGPYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKAAVVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSVFITIWTVVRIYFEDFGCWDTIINSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRPPDIGKNDSSPYSRLAKSTLLLIPLFGIHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGATCSTQVSMLTRVSPSARRSSSFQAEVSLV
  
Inhibitor
Name:
BDBM50241256
Synonyms:
CHEMBL233000 | N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C16H14N2OS
Mol. Mass.:
282.36
SMILES:
O=C(Nc1sc2CCCCc2c1C#N)c1ccccc1
Structure:
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