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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282623
Substrate
n/a
Meas. Tech.
ChEMBL_36775 (CHEMBL650297)
IC50
5500±n/a nM
Citation
 Dorsch, D; Mederski, WW; Beier, N; Lues, I; Minck, K; Schelling, P (6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists Bioorg Med Chem Lett 4:1297-1302 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50282623
Synonyms:
6-{2-(4-Methoxy-phenyl)-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazol-5-yl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one | CHEMBL284546
Type:
Small organic molecule
Emp. Form.:
C33H28N8O2
Mol. Mass.:
568.6278
SMILES:
COc1ccc(cc1)-c1nc2cc(ccc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C1=NNC(=O)CC1C |t:41|
Structure:
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