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Target
Cholesteryl ester transfer protein
Ligand
BDBM50286609
Substrate
n/a
Meas. Tech.
ChEMBL_44154 (CHEMBL653305)
IC50
23000±n/a nM
Citation
 Coval, SJ; Conover, MA; Mierzwa, R; King, A; Puar, MS; Phife, DW; Pai, J; Burrier, RE; Ahn, H; Boykow, GC; Patel, M; Pomponi, SA Wiedendiol-A and -B, cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri Bioorg Med Chem Lett 5:605-610 (1995)    Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50286609
Synonyms:
1-((4aS,12bR)-9,10-Diacetyl-4,4,4a,12b-tetramethyl-1,3,4,4a,5,6,6a,9,12a,12b-decahydro-2H-benzo[a]xanthen-11-yl)-ethanone | CHEMBL347038
Type:
Small organic molecule
Emp. Form.:
C27H36O4
Mol. Mass.:
424.5723
SMILES:
CC(=O)C1C=C2OC3CC[C@@]4(C)C(C)(C)CCC[C@]4(C)C3C=C2C(C(C)=O)=C1C(C)=O |c:23,29,t:4|
Structure:
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