Reaction Details Report a problem with these data
Target
Tissue alpha-L-fucosidase
Ligand
BDBM50104403
Substrate
n/a
Meas. Tech.
ChEBML_34082
Ki
16±n/a nM
Citation
 Robina, I; Moreno-Vargas, AJ; Fernández-Bolaños, JG; Fuentes, J; Demange, R; Vogel, P New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives. Bioorg Med Chem Lett 11:2555-9 (2001) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50104403
Synonyms:
(2R,3S)-2-Amino-5-methyl-piperidine-3,4-diol | CHEMBL85218
Type:
Small organic molecule
Emp. Form.:
C6H14N2O2
Mol. Mass.:
146.1876
SMILES:
CC1CN[C@@H](N)[C@H](O)C1O
Structure:
Search PDB for entries with ligand similarity: