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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50024813
Substrate
n/a
Meas. Tech.
ChEBML_153309
Ki
258000±n/a nM
Citation
 Sall, DJ; Grunewald, GL Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site. J Med Chem 30:2208-16 (1988) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50024813
Synonyms:
1,2,3,4-Tetrahydro-1,4-methano-naphthalen-9-ylamine | CHEMBL299436
Type:
Small organic molecule
Emp. Form.:
C11H13N
Mol. Mass.:
159.2276
SMILES:
NC1C2CC[C@H]1c1ccccc21 |TLB:0:1:6.11:3.4,7:6:1:3.4,10:11:1:3.4|
Structure:
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