Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50024842
Substrate
n/a
Meas. Tech.
ChEBML_153309
Ki
108000±n/a nM
Citation
 Sall, DJ; Grunewald, GL Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site. J Med Chem 30:2208-16 (1988) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50024842
Synonyms:
9-Amino-1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-ol | CHEMBL71563
Type:
Small organic molecule
Emp. Form.:
C11H13NO
Mol. Mass.:
175.227
SMILES:
N[C@H]1C2CCC1c1cc(O)ccc21 |TLB:0:1:6.12:4.3,THB:7:6:1:4.3|
Structure:
Search PDB for entries with ligand similarity: