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Target
Integrase
Ligand
BDBM50115581
Substrate
n/a
Meas. Tech.
ChEMBL_88608 (CHEMBL873101)
IC50
>100000±n/a nM
Citation
 Pais, GC; Zhang, X; Marchand, C; Neamati, N; Cowansage, K; Svarovskaia, ES; Pathak, VK; Tang, Y; Nicklaus, M; Pommier, Y; Burke, TR Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. J Med Chem 45:3184-94 (2002) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50115581
Synonyms:
(Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid | 2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid | CHEMBL108423 | CHEMBL185721 | CHEMBL573638
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
OC(=O)C(=O)CC(=O)c1ccc(Oc2ccccc2)cc1
Structure:
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