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Target
Histamine H3 receptor
Ligand
BDBM22888
Substrate
n/a
Meas. Tech.
ChEMBL_83644 (CHEMBL693106)
Ki
84±n/a nM
Citation
 Jablonowski, JA; Grice, CA; Chai, W; Dvorak, CA; Venable, JD; Kwok, AK; Ly, KS; Wei, J; Baker, SM; Desai, PJ; Jiang, W; Wilson, SJ; Thurmond, RL; Karlsson, L; Edwards, JP; Lovenberg, TW; Carruthers, NI The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 46:3957-60 (2003) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM22888
Synonyms:
1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea | Burimamide | CHEMBL12160
Type:
Small organic molecule
Emp. Form.:
C9H16N4S
Mol. Mass.:
212.315
SMILES:
CNC(=S)NCCCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: