Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50172545
Substrate
n/a
Meas. Tech.
ChEMBL_320853 (CHEMBL884778)
Ki
2.8±n/a nM
Citation
 Deng, H; Gifford, AN; Zvonok, AM; Cui, G; Li, X; Fan, P; Deschamps, JR; Flippen-Anderson, JL; Gatley, SJ; Makriyannis, A Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor. J Med Chem 48:6386-92 (2005) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50172545
Synonyms:
(2-Iodo-phenyl)-[1-((S)-1-methyl-piperidin-2-ylmethyl)-1H-indol-3-yl]-methanone | (2-Iodo-phenyl)-[1-(1-methyl-piperidin-2-ylmethyl)-1H-indol-3-yl]-methanone | CHEMBL364266
Type:
Small organic molecule
Emp. Form.:
C22H23IN2O
Mol. Mass.:
458.3353
SMILES:
CN1CCCCC1Cn1cc(C(=O)c2ccccc2I)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: