Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50186371
Substrate
n/a
Meas. Tech.
ChEMBL_365696 (CHEMBL868538)
EC50
16.4±n/a nM
Citation
 Odagami, T; Tsuda, Y; Kogami, Y; Kouji, H; Okada, Y Design of cyclic peptides with agonist activity at melanocortin receptor-4. Bioorg Med Chem Lett 16:3723-6 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50186371
Synonyms:
CHEMBL264120 | c(his-D-phe-arg-trp-Aoc)
Type:
Small organic molecule
Emp. Form.:
C40H54N10O4
Mol. Mass.:
738.9214
SMILES:
NC(N)=NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC[C@H](Cc2cnc[nH]2)NC(=O)CCCCCCCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O |wU:21.22,40.42,7.6,wD:11.11,(14.11,-13.67,;13.11,-12.52,;13.62,-11.08,;11.62,-12.8,;10.62,-11.65,;9.13,-11.93,;8.13,-10.78,;6.64,-11.06,;5.6,-9.87,;4.18,-9.13,;4.11,-7.53,;2.85,-9.99,;2.84,-8.38,;1.44,-7.58,;1.43,-5.97,;.03,-5.18,;-1.36,-5.99,;-1.33,-7.78,;.06,-8.4,;1.47,-10.67,;.04,-10.09,;-1.33,-9.3,;-2.1,-7.97,;-3.62,-7.97,;-4.53,-6.74,;-5.97,-7.21,;-5.97,-8.73,;-4.52,-9.2,;-2.59,-10.19,;-2.67,-11.73,;-4.47,-12.71,;-1.28,-12.48,;-1.28,-14.08,;.11,-14.88,;1.49,-14.07,;2.87,-14.87,;2.87,-16.48,;4.47,-17.01,;5.02,-15.59,;4.11,-14.39,;6.58,-15.28,;7.56,-16.44,;7.05,-17.88,;5.59,-18.3,;5.55,-19.83,;6.98,-20.34,;7.55,-21.74,;9.06,-21.95,;9.99,-20.74,;9.41,-19.34,;7.91,-19.14,;7.02,-13.81,;6.1,-12.57,;4.53,-12.87,)|
Structure:
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