Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50199042
Substrate
n/a
Meas. Tech.
ChEMBL_411597 (CHEMBL907248)
IC50
24±n/a nM
Citation
Ikegashira, K; Oka, T; Hirashima, S; Noji, S; Yamanaka, H; Hara, Y; Adachi, T; Tsuruha, J; Doi, S; Hase, Y; Noguchi, T; Ando, I; Ogura, N; Ikeda, S; Hashimoto, H Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors. J Med Chem 49:6950-3 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50199042
Synonyms:
13-cyclohexyl-5-(dimethylcarbamoylmethyl)-6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indole-10-carboxylic acid | CHEMBL385407
Type:
Small organic molecule
Emp. Form.:
C27H31N3O3
Mol. Mass.:
445.5533
SMILES:
CN(C)C(=O)CN1CCn2c(c(C3CCCCC3)c3ccc(cc23)C(O)=O)-c2ccccc12