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Target
UDP-glucuronosyltransferase 2B7
Ligand
BDBM50211775
Substrate
n/a
Meas. Tech.
ChEMBL_436438 (CHEMBL904746)
IC50
100±n/a nM
Citation
 Bichlmaier, I; Kurkela, M; Joshi, T; Siiskonen, A; Rüffer, T; Lang, H; Suchanova, B; Vahermo, M; Finel, M; Yli-Kauhaluoma, J Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives. J Med Chem 50:2655-64 (2007) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 2B7
Synonyms:
2.4.1.17 | 3,4-catechol estrogen-specific UDPGT | UD2B7_HUMAN | UDP-glucuronosyltransferase 2B7 | UDP-glucuronosyltransferase 2B9 | UDPGT 2B7 | UDPGT 2B9 | UDPGTh-2 | UGT2B7 | UGTB2B9 | Uridine-5'-diphosphoglucuronosyltransferase 2B7
Type:
Enzyme
Mol. Mass.:
60705.98
Organism:
Homo sapiens (Human)
Description:
P16662
Residue:
529
Sequence:
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
  
Inhibitor
Name:
BDBM50211775
Synonyms:
((1S,3aR,4S,8aR,9S)-4,8,8-trimethyl-decahydro-1,4-methano-azulen-9-yl)-methanol | CHEMBL388140
Type:
Small organic molecule
Emp. Form.:
C15H26O
Mol. Mass.:
222.3663
SMILES:
C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2CO |TLB:2:1:10.11:8,THB:11:12:9.13:2.3.5.4,5:8:10.11:13.1,14:13:10.11:8,0:1:10.11:8|
Structure:
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