Reaction Details Report a problem with these data
Target
Diacylglycerol kinase 1
Ligand
BDBM50206499
Substrate
n/a
Meas. Tech.
ChEMBL_454750 (CHEMBL885685)
IC50
>500000±n/a nM
Citation
 Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem 15:3065-81 (2007) [PubMed]  Article 
Target
Name:
Diacylglycerol kinase 1
Synonyms:
DAG kinase 1 | DGK 1 | DGK1 | DGK1_DROME | Dgk | Diglyceride kinase 1
Type:
PROTEIN
Mol. Mass.:
132987.69
Organism:
Drosophila melanogaster
Description:
ChEMBL_454750
Residue:
1211
Sequence:
MNIGIAAPKWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKKSQMHHHQATHFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS
  
Inhibitor
Name:
BDBM50206499
Synonyms:
9-(2'-O-pentanoyl-beta-D-arabinofuranosyl)guanine | CHEMBL401029
Type:
Small organic molecule
Emp. Form.:
C15H21N5O6
Mol. Mass.:
367.3571
SMILES:
CCCCC(=O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c1nc(N)[nH]c2=O
Structure:
Search PDB for entries with ligand similarity: