Reaction Details Report a problem with these data
Target
Xaa-Pro dipeptidase
Ligand
BDBM50232507
Substrate
n/a
Meas. Tech.
ChEMBL_461055 (CHEMBL944087)
IC50
>10000±n/a nM
Citation
Kim, D; Kowalchick, JE; Brockunier, LL; Parmee, ER; Eiermann, GJ; Fisher, MH; He, H; Leiting, B; Lyons, K; Scapin, G; Patel, SB; Petrov, A; Pryor, KD; Roy, RS; Wu, JK; Zhang, X; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem 51:589-602 (2008) [PubMed] Article
More Info.:
Target
Name:
Xaa-Pro dipeptidase
Synonyms:
PEPD | PEPD_HUMAN | PRD
Type:
PROTEIN
Mol. Mass.:
54541.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_159887
Residue:
493
Sequence:
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK
Inhibitor
Name:
BDBM50232507
Synonyms:
2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide hydrochloride | CHEMBL556979
Type:
Small organic molecule
Emp. Form.:
C20H22F6N6O2
Mol. Mass.:
492.4181
SMILES:
CN(C)C(=O)CC1N(CCn2c1nnc2C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |w:6.5|