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Target
Stromelysin-1
Ligand
BDBM50373178
Substrate
n/a
Meas. Tech.
ChEMBL_467083 (CHEMBL934766)
IC50
31000±n/a nM
Citation
 Ayers, S; Zink, DL; Powell, JS; Brown, CM; Grund, A; Bills, GF; Platas, G; Thompson, D; Singh, SB Noreupenifeldin, a tropolone from an unidentified ascomycete. J Nat Prod 71:457-9 (2008) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50373178
Synonyms:
PYCNIDIONE
Type:
Small organic molecule
Emp. Form.:
C33H40O7
Mol. Mass.:
548.6665
SMILES:
Cc1cc(=O)c(O)cc2O[C@]3(C)C\C=C\C(C)(C)C[C@@H]4Cc5c(O[C@@]4(C)[C@@H](O)C[C@H]3Cc12)cc(O)c(=O)cc5C |t:13|
Structure:
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