Reaction Details
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11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50377887
Substrate
n/a
Meas. Tech.
ChEMBL_480088 (CHEMBL934813)
IC50
22±n/a nM
Citation
Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 18:3412-6 (2008) [PubMed] Article More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Inhibitor
Name:
BDBM50377887
Synonyms:
CHEMBL255259
Type:
Small organic molecule
Emp. Form.:
C18H19ClFN3
Mol. Mass.:
331.815
SMILES:
F[C@H]1C[C@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 |wD:3.5,1.0,(11.81,-32.18,;11.81,-30.64,;12.91,-29.55,;11.82,-28.46,;10.73,-29.54,;13.16,-27.66,;13.56,-26.18,;15.11,-26.11,;15.65,-27.55,;17.13,-27.96,;18.21,-29.06,;18.62,-27.57,;14.44,-28.51,;14.52,-30.05,;13.81,-31.42,;15.35,-31.35,;10.5,-27.69,;10.49,-26.15,;9.15,-25.39,;7.82,-26.17,;6.48,-25.42,;7.84,-27.72,;9.18,-28.47,)|
Structure:
