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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50303770
Substrate
n/a
Meas. Tech.
ChEMBL_597554 (CHEMBL1047029)
IC50
23600±n/a nM
Citation
 Huber, K; Schemies, J; Uciechowska, U; Wagner, JM; Rumpf, T; Lewrick, F; Süss, R; Sippl, W; Jung, M; Bracher, F Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins). J Med Chem 53:1383-6 (2010) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50303770
Synonyms:
(E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzylidene)-indolin-2-one | CHEMBL569449
Type:
Small organic molecule
Emp. Form.:
C15H7Br2Cl2NO2
Mol. Mass.:
463.936
SMILES:
Oc1c(Br)cc(\C=C2/C(=O)Nc3c2ccc(Cl)c3Cl)cc1Br
Structure:
Search PDB for entries with ligand similarity: