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Found 156 with Last Name = 'rumpf' and Initial = 't'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148829(CHEMBL3769432)
Affinity DataIC50:  1nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346543(CHEMBL1797750)
Affinity DataIC50:  98nMAssay Description:Inhibition of SIRT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148782(CHEMBL3770049)
Affinity DataIC50:  180nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148789(CHEMBL3771286)
Affinity DataIC50:  210nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148784(CHEMBL3769991)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50336799(5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148791(CHEMBL3770797)
Affinity DataIC50:  310nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148792(CHEMBL3771296)
Affinity DataIC50:  320nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148783(CHEMBL3771164)
Affinity DataIC50:  420nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  440nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148793(CHEMBL3770258)
Affinity DataIC50:  480nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148794(CHEMBL3771278)
Affinity DataIC50:  540nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148795(CHEMBL3769999)
Affinity DataIC50:  540nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50400734(CHEMBL1591531)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346550(CHEMBL270110)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50373763(CHEMBL270292)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50336799(5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of GST-tagged recombinant human SIRT2 using MPSDKTIGG as substrate by liquid scintillation counting analysis in presence of [3H]-acetic ac...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148803(CHEMBL3771012)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human SIRT2 using RHKK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148796(CHEMBL3770983)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148804(CHEMBL3770654)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148753(CHEMBL3770429)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148797(CHEMBL3769691)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400733(CHEMBL2203548)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148798(CHEMBL3770426)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148805(CHEMBL3771035)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50400732(CHEMBL2203543)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50400731(CHEMBL2203547)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148828(CHEMBL3770979)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human SIRT2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50400734(CHEMBL1591531)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400731(CHEMBL2203547)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50400734(CHEMBL1591531)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of recombinant SIRT3 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human C-terminally His6-tagged Sirt3 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148776(CHEMBL3769988)
Affinity DataIC50:  3.75E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148806(CHEMBL3769677)
Affinity DataIC50:  4.72E+3nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346546(CHEMBL1797926)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50400733(CHEMBL2203548)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50400724(CHEMBL1714005)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50400723(CHEMBL2203546)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400732(CHEMBL2203543)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50400730(CHEMBL2203544)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50400730(CHEMBL2203544)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346546(CHEMBL1797926)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346551(CHEMBL1795371)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM74978(1,3-dihydrobenzo[e]benzimidazole-2-thione | CHEMBL...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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