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Target
Beta-1 adrenergic receptor
Ligand
BDBM50313974
Substrate
n/a
Meas. Tech.
ChEMBL_615506 (CHEMBL1105984)
IC50
12000±n/a nM
Citation
 Goble, SD; Wang, L; Howell, KL; Bansal, A; Berger, R; Brockunier, L; DiSalvo, J; Feighner, S; Harper, B; He, J; Hurley, A; Hreniuk, D; Parmee, E; Robbins, M; Salituro, G; Sanfiz, A; Streckfuss, E; Watkins, E; Weber, AE; Struthers, M; Edmondson, SD Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles. Bioorg Med Chem Lett 20:1895-9 (2010) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50313974
Synonyms:
(R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)-5-methyl-2-(pyrrolidin-1-yl)benzamide | CHEMBL1078696
Type:
Small organic molecule
Emp. Form.:
C27H32N4O2
Mol. Mass.:
444.5686
SMILES:
Cc1ccc(N2CCCC2)c(c1)C(=O)Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: