Affinity DataIC50: 5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as [14C]-glycine transportMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as [14C]-glycine transportMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as [14C]-glycine transportMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 433nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as [14C]-glycine transportMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as [14C]-glycine transportMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 970nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair